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Much of the research work performed at Dana-Farber has resulted in treatment breakthroughs and new standards of care for patients with metastatic disease. People with metastatic (stage IV) breast cancer that has spread to the brain. 2020 Apr 18;70:153218. doi: 10.1016/j.phymed.2020.153218. Methods. MBC Connect Empowers Metastatic Breast Cancer Community with New … Several hundred to several thousand people may take part in a phase IV study. The EA Navigator explains what EA is, who may be eligible, how the request process works, as well as the regulatory and policy issues around EA. One factor is that information about current trials and how to enroll in a trial are often not well understood. According to the American Cancer Society, about 1,000 potential medicines are tested before one makes it to clinical trials. clinical trial, you will do better on that clinical trial than if you got the These studies help improve the overall standard of care. Earlier data from the trial, led to the FDA approval of the antibody-drug conjugate in December 2019 in adult patients with unresectable or metastatic HER2-positive breast cancer who … Background: Oral chemotherapy is one of the options for the treatment of endocrine non-responsive metastatic breast cancer. Even if you decide not to join a clinical trial now, it doesn’t mean you can’t join one later, if you’re eligible. These clinical trials … To determine how well neratinib works in treating breast cancer that has spread to the brain, as well as the effect that it has on cognitive functioning. Naumann, a gynecologic oncologist and associate medical director of clinical trials at Levine Cancer Institute, Atrium Health in Charlotte, North Carolina, reported that 1 patient in this trial who received this therapy still has no evidence of disease a full year after treatment completion. Clinical trials offer the chance to try new treatments that may be more effective than standard treatments. Was this article helpful? The Expanded Access (EA) Navigator tool serves as a clearinghouse of information and resources to help patients and their doctors more easily access information that could impact treatment decisions. Dallas, TX 75380, helpline@komen.org In a clinical trial, it is a direct way to see if a treatment helped people live longer compared to another treatment. Find out how they work and whether one might be right for you. Join our online community to connect, share, and find peer support. Fighting for treatments to extend living... 1-888-500-0370 mbcn@mbcn.org. A clinical trial can be a chance to try a new cancer treatment that's not available for everyone. Clinical Trials for Metastatic Breast Cancer, Special Report: COVID-19’s Impact on Breast Cancer Care, Talking to Your Family and Friends About Breast Cancer, Fertility and Pregnancy Issues During and After Breast Cancer, Understanding Breast Cancer Risk and How to Lower It, Metastatic Breast Cancer Treatment and Planning, Seven Things People With Metastatic Breast Cancer Want You to Know About Joining a Clinical Trial, Tamoxifen (Brand Names: Nolvadex, Soltamox), Expanded Access and Right to Try: Alternative Paths to Experimental Treatments for Metastatic Breast Cancer, our commitment to providing complete, accurate, and private breast cancer information. A clinical trial is a study that every treatment must go through before it is reviewed by the Food and Drug Administration, or the FDA. Standard Treatment vs. Clinical Trials; Metastatic Breast Cancer Trial Search; Surgery. Many of the studies reviewed in the Breastcancer.org Research News section are reports on clinical trials. Some treatments may even go on to be used to treat early stage breast cancer or other types of cancer. Breast Cancer Res Treat. Many new treatments for metastatic breast cancer are under study. Breastcancer.org’s EIN is 23-3082851. Breastcancer.org is a registered 501(c)(3) nonprofit organization dedicated to providing information and community to those touched by this disease. Visit Metastatic Trial Search from BreastCancerTrials.org. CirCe01 was a prospective, multicentre, randomised trial (NCT01349842) that included patients with MBC after two systemic LC. ANSWER You may want to consider clinical trials. The FDA looks for 2 main things in each clinical trial—efficacy and safety. Learn more about what Komen is doing to help people with any stage of breast cancer find and participate in clinical trials. “You don’t see that often,” he said. Subscribe to our podcast for conversations on the issues that matter most. Can we help guide you? Should I consider clinical trials to treat my metastatic (stage IV) breast cancer? Set to be helmed by George Thomas Budd, MD, staff physician at the Cleveland Clinic’s Taussig Cancer Center, the trials will also include men, who constitute about 1% of all breast cancer … Epub 2017 Nov 24. A clinical trial can be a chance to try a new cancer treatment that's not available for everyone. It includes a data… Clear all Advanced. The prevalence of these mutations and their potential impact on clinical outcomes has not been established. The Metastatic Breast Circulating Biomarker (MBCB) study was established at the Peter MacCallum Cancer Centre (Melbourne, Australia) in June 2015 to assess the feasibility and utility of applying routine comprehensive ctDNA profiling in mBC patients to guide clinical management. This advanced cancer stage is harder to treat, and effective options can be limited. Active Description. For more information on how to find clinical trials, the benefits and risks of clinical trials, and what you should know before deciding to participate in one, visit the Clinical Trials section. The following organizations listed in alphabetical order offer free, searchable listings of cancer clinical trials. This clinical trial is a Phase 1-2, open-label, multi-center, dose-escalation and expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of daily oral administration of OP-1250. October 25, 2018 at 12:56 pm; 17 replies; TODO: Email modal placeholder. Skip to main content 1-800-4-CANCER Live Chat Publications Dictionary Breast cancer trials never use a placebo (an inactive medicine or “sugar pill”) instead of standard treatment. may be able to access an experimental drug through the Expanded Access or Right After learning she had metastatic breast cancer, Karen Peterson rejected her doctor's advice to try chemo and instead did her own research to find a clinical trial that might save her life. Tucatinib is an investigational, oral, highly selective inhibitor of the HER2 tyrosine kinase. Please select a valid location from the dropdown. Min. If your medical center doesn’t offer clinical trials, you can get a referral from your oncologist to a cancer center that does. Clinical trials are just one type of research that's done before a new treatment becomes available to people. You can use a new search engine to look for metastatic breast cancer trials that might be right for you. Below is a link for you to search and educate yourself to any possible treatment options for metaplastic breast cancer for you to address with your oncologist. Clinical trials are used for all types and stages of breast cancer. This is a phase II single arm, open-label study of SM-88 used with methoxsalen, phenytoin, and sirolimus (MPS) in metastatic HR+/HER2- breast cancer. Earlier data from the trial, led to the FDA approval of the antibody-drug conjugate in December 2019 in adult patients with unresectable or metastatic HER2-positive breast cancer who … Yes / No. Share. It is designed to determine efficacy, defined as the objective response rate (ORR) of this investigational treatment. 3 distinct metastatic sites, at least one measurable lesion which is at least 1 cm or larger in largest diameter. The evolution of thought in assessing benefit in clinical trials of systemic therapy for metastatic breast cancer (MBC) is well documented, with most agents garnering regulatory approval based either on an advantage in overall survival (OS), time to progression (TTP), or progression-free survival (PFS) over an existing standard of care or objective response rate (ORR). Biopsy-proven breast cancer, metastatic (persistent or recurrent). They can also study other parts of care including risk reduction, diagnosis and screening. © 2021 Breastcancer.org - All rights reserved. Search for Clinical Trials by condition, keyword or trial number. Clinical trials are an important step in discovering new treatments for breast cancer and other diseases as well as new ways to detect, diagnose, and reduce the risk of disease. At the same time, hundreds of thousands of people have been helped and are alive because other people chose to participate in a trial that resulted in a new, more effective treatment. Susan G. Komen® supported the Reagan-Udall Foundation and the Food and Drug Administration (FDA) in the development of the Expanded Access Navigator website. Clinical trials test the safety and benefits of new treatments as well as new combinations (or new doses) of standard treatments. Find an NCI-supported clinical trial—and learn how to locate other research studies—that may be right for you or a loved one. The treatment for postmenopausal women diagnosed with hormone receptor positive (HR+) metastatic breast cancer (mBr) includes endocrine therapy However, de novo or acquired resistance to endocrine therapy remains an important clinical problem. Clinical trials for metastatic breast cancer are a way of potentially gaining access to cutting-edge therapies. This is a study consisting of four cohorts in this setting. Share your location or enter your city or zip code to find studies near you. The purpose of this study was to assess patient characteristics and clinical outcomes for patients with MBC treated on phase I clinical trials. Who is this for? The FDA’s approval clears the way for the Cleveland Clinic to start Phase I clinical trials of the vaccine. Global biotechnology company Immutep (ASX: IMM) has announced its Chinese partner EOC Pharma will commence a phase II clinical trial to evaluate the efficacy and safety of lead drug eftilagimod alpha in treating metastatic breast cancer.. They can also be an opportunity to advance knowledge and treatments for the disease. The University of Virginia is conducting a clinical research study for adults ages 18 and over, who have metastatic breast cancer. This field is for validation purposes and should be left unchanged. This organizationprovides information on clinical trials. To fulfil the requirement of HR+ disease, a breast cancer must express ER with or without co-expression of progesterone receptor. MBCN in the News. Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial Phytomedicine. 13770 Noel Road, Suite 801889 Please note that if you select one of these websites, you will leave Cancer.Net. All trials on the list are supported by NCI.. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. If you’ve been diagnosed with metastatic breast cancer, consider joining a clinical trial when your oncologist is considering changing treatments, before starting a new treatment or when there are limited treatment options. 20 Jul 2019. Clinical trials for those with advanced breast cancer often center on studying new drug treatments. Clinical trials show researchers what does and doesn’t work in people. To request their help, complete the online form. Learn more. Clinical trials. Center for Information and Study on Clinical Research Participation (CISCRP). All treatments for breast cancer — including targeted therapies, aromatase inhibitors, tamoxifen, radiation, and more — were studied in several clinical trials. To determine the maximally tolerated dose (MTD) of intratumoral administration of an Edmonston strain measeles virus genetically engineered to express NAP (MV-s-NAP) in patients with metastatic breast cancer; to determine the safety and toxicity of on-time and serial administration of MV-s-NAP in patients with metastic breast cancer. You may be offered the opportunity to take part in a clinical trial at some point during your treatment for breast cancer. Metastatic Cancer Clinical Trials. to Try pathways. 1. EIN 75-1835298. The safety and efficacy … Metastatic Breast Cancer Trial Search Save as Favorite. Print. However, even those who don’t get the new treatment still get the standard treatment, just as they would if they didn’t join the trial. Lymph Node Removal & Lymphedema; Breast Reconstruction; Lumpectomy; Mastectomy; Chemotherapy; Radiation Therapy; Hormone Therapy ; Targeted Therapy; Physical Activity, Wellness & Nutrition; Follow-Up Care; Myths. Search for content, post, videos. While clinical trials are important, the choice to participate in one is very personal and depends on your unique situation. Trial 17-512: A randomized phase II trial of carboplatin with or without nivolumab in first-line metastatic triple-negative breast cancer Principal investigator: Sara M. Tolaney, MD, MPH. DESTINY Breast Cancer Clinical Trials. Our breast cancer clinical trial finder provides an easy way to search for a clinical trial in breast cancer. A clinical trial could also be a survey of patient attitudes toward treatments, or of patients’ relationships with their families. Download a fact sheet on some basic information about clinical trials to help you be better prepared to discuss your options with your doctor. The uncertainty of not knowing how a clinical trial will turn out can make it hard to decide whether you want to participate. Sign up for emails about breast cancer news, virtual events, and more. The staff at CISCRPwill conduct free clinical trial searches. Clinical trials are research studies in which people agree to try new therapies (under careful supervision) in order to help doctors identify the best treatments with the fewest side effects. In metastatic breast cancer, clinical trials compare standard FDA-approved treatments to new therapies, or they study new therapies.All of today’s standard therapies for stage IV breast cancer were once part of clinical trials.. Clinical trials look at new ways to prevent, detect, or treat disease. If you or a loved one needs information or resources about clinical trials, call our Clinical Trial Information Helpline at 1-877 GO KOMEN (1-877- 465- 6636) or email clinicaltrialinfo@komen.org. Susan G. Komen® Breast Cancer Clinical Trial Information Helpline. Approximately 5% of Australians diagnosed with cancer currently participate in clinical trials. Breast Cancer Clinical Trial Information Helpline, Susan G. Komen Findings from clinical trials determine whether or not new treatments will become a part of the standard of care for metastatic breast cancer. Participating in a Clinical Trial. Find out how they work and whether one might be right for you. Clinical trials are used for all types and stages of breast cancer. MBCN c/o SHARE 165 West 46th St. Suite 712 New York, NY 10036. Subscribe; My account; Business; Pharma; Medtech; Biotech; Science; Careers; Events; Press Rooms; About us. Search for closest city to find more detailed information on a research study in your area. Sign in to receive recommendations . Many focus on new treatments to learn if a new treatment is safe, effective, and possibly better than the existing treatments. Metastatic breast cancer clinical trials: Metastatic breast cancer is when the disease has spread to other areas of the body. Dana-Farber/Brigham and Women's Breast Cancer Treatment Center is conducting multiple clinical trials to study the effect of new targeted drugs, particularly in patients with metastatic disease. Many focus on new treatments to learn if a new treatment is safe, effective, and possibly better than the existing treatments. According to the American Cancer Society, a shortage of people taking part in clinical trials is the biggest reason trials aren't done. According to their findings, women with metastatic breast cancer often do want to enroll in clinical trials so that they can try new treatments that might extend their lives. Clinical trials are research studies that evaluate the safety and effectiveness of new treatment approaches for diseases. same exact medicine off the clinical trial. * Learn more Other types of research studies. Clinical trials are research studies that involve people. Understanding Metastatic Breast Cancer Clinical Trials. New medicines must first be discovered, purified, and tested in preclinical trials before researchers even think about clinical trials. These studies are less common than Phase I, II, or III trials. My wife has Metastatic Breast Cancer and I am exploring other treatment options to help her battle it. Expanded Access (EA) is also known as “compassionate use.” It gives patients access to drugs before they have FDA approval. Some clinical trials compare a new treatment to standard treatment. Talk with your oncologist about clinical trials. trial. You will receive potential research study matches. Approximately 15 to 20% of breast cancers overexpress human epidermal growth factor receptor 2 (HER2). This advanced cancer stage is harder to treat, and effective options can be limited. Failed ≥1 line of therapy (endocrine or chemotherapy) for metastatic disease. clinical trials, including how to enroll and the informed consent process, a list of questions to ask your doctor about clinical trials, Information about clinical trial resources. Online ahead of print. Share. Every advance in treating breast cancer has been the result of a clinical trial. According to their findings, women with metastatic breast cancer often do want to enroll in clinical trials so that they can try new treatments that might extend their lives. Metaplastic Clinical Trials ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical trials and studies of human participants conducted around the world. Breast implant illness (BII) is a term that some women and doctors use to refer to a wide range... Last modified on May 9, 2019 at 12:53 PM. Breast Cancer Clinical Trials & Research. Clinical trials also help researchers and doctors decide if the side effects of a new treatment are acceptable when weighed against the benefits offered by the new treatment. On average, a new medicine to treat breast cancer has been studied for at least 6 years (and sometimes many more) before researchers begin to test it in a clinical trial. This may be needed when patients have exhausted their treatment options and are not eligible for (or unable to participate in) a clinical trial. Many hormone receptor positive breast cancers demonstrate overexpression of cyclin D. Cyclin D interacts directly with cyclin-dependent kinases 4 … The trial follows encouraging results from an ongoing AIPAC (Active Immunotherapy Paclitaxel) phase IIb study launched earlier this year which … It's estimated that fewer than 5% of adults diagnosed with cancer will take part in a clinical trial. Most of these are drug therapies. A listing of Metastatic Cancer medical research trials actively recruiting patient volunteers. Participating in a Clinical Trial Clinical trials are controlled, scientific studies that test the safety and effectiveness of specific therapeutic interventions. Find a list of questions to ask your doctor about clinical trials. Clinical Trials Finder. The open EA programs are listed on the National Institutes of Health’s clinical trials website, www.clinicaltrials.gov. Efficacy means how well a treatment works in fighting the disease and/or its symptoms. They usually take place after the treatment has been approved for standard use. In rare cases, clinical trial volunteers have been hurt by the treatment or procedure being tested. They look at the safety of proposed treatments and whether they work. Clinical Trials for Metastatic Breast Cancer (MBC) Clinical trials can offer a new therapy or treatment not yet available. If you aren’t eligible for a clinical trial, you Filter By. 1-877-465-66361-877 GO KOMEN, For breast health or breast cancer information, please call the Breast Care Helpline: 1-877-465-6636 or helpline@komen.org, For clinical trial information, please call the Clinical Trial Information Helpline: 1-877-465-6636 or clinicaltrialinfo@komen.org, © 2021 Susan G. Komen is a 501(c)(3) non-profit organization. Home Treatment and Side Effects Clinical Trials Metastatic Breast Cancer Trial Search. The helpline offers breast cancer clinical trial education and support, such as: Use the Metastatic Trial Search Tool to find a clinical trial that’s right for you. Understanding more about clinical trials and how they work may help individuals with metastatic breast cancer decide if they are an option for them. All the clinically relevant data have been analysed in this article. Komen Perspectives ‘Read our perspective on clinical trials. Clinical Trials for Metastatic Breast Cancer and other treatment options - Advanced breast cancer. The only reason not to be on a Randomized phase 2 clinical trial of nab-paclitaxel + MEDI4736 (durvalumab) + neoantigen vaccine vs. nab-paclitaxel + MEDI4736 (durvalumab) in patients with metastatic triple negative breast cancer Phase II Principal Investigator Gillanders, William Disease Site Breast… Some treatments may even go on to be used to treat early stage breast cancer or other types of cancer. The clinical trials on this list are for breast cancer treatment. In metastatic breast cancer trials, this is typically a secondary, or less important, endpoint of the trial because it can take a long time to achieve and researchers hope to bring new treatments to patients as quickly as possible. CenterWatch. "If you're eligible for a CirCe01 trial aimed to assess the clinical utility of circulating tumour cell (CTC)-based monitoring in metastatic breast cancer (MBC) patients beyond the third line of chemotherapy (LC). This phase II trial studies how well nab-paclitaxel, durvalumab, and tremelimumab with or without personalized synthetic long peptide vaccine (neoantigen vaccine) works in treating patients with triple negative breast cancer that has spread to other places in the body (metastatic). Patients with human epidermal growth factor receptor 2 (HER2)–positive metastatic breast cancer who have disease progression after therapy with multiple HER2-targeted agents have limited treatment options. During a clinical trial, you will always be treated with medicine, either a standard therapy or the therapy under study. These are studies that test new ways to treat HER2-positive breast cancer. In Cohort 1, the safety and efficacy of ipatasertib (ipat) in combination with atezolizumab (atezo) and paclitaxel (pac) or nab-paclitaxel will be evaluated for participants with locally advanced or metastatic triple-negative breast cancer (TNBC) who have not previously received chemotherapy. Findings from clinical trials determine whether or not new treatments will become a part of the standard of care for metastatic breast cancer. Learn more about services at Mayo Clinic. While living with metastatic breast cancer, there are ways to help improve your physical, emotional, and financial well-being. Clinical trials are controlled, scientific studies that test the safety and effectiveness of specific therapeutic interventions. clinical trial is if you don't meet eligibility requirements for that Several phase 1 and 2 studies have shown that PARP inhibitors have single-agent activity in patients with metastatic breast cancer and a germline BRCA mutation. Safety, Efficacy, and Biomarker Analysis of Pyrotinib in Combination with Capecitabine in HER2-Positive Metastatic Breast Cancer Patients: A Phase I Clinical Trial Clin Cancer Res . Learning whether a new drug is better than standard treatment can also help others. Read the blog, How Do You Thank Someone For Time. You will get either the new treatment or the standard treatment. Pharma Business; … 13 Oct 2019 . Clinical Trials for Metastatic Breast Cancer (MBC) Clinical trials can offer a new therapy or treatment not yet available. Enhertu approved in the EU for the treatment of HER2-positive metastatic breast cancer. This phase II trial studies how well nab-paclitaxel, durvalumab, and tremelimumab with or without personalized synthetic long peptide vaccine (neoantigen vaccine) works in treating patients with triple negative breast cancer that has spread to other places in the body (metastatic). However, these women also say they are not often told about clinical trials for new treatments, especially if the trials are being done outside of their hospital. Naumann, a gynecologic oncologist and associate medical director of clinical trials at Levine Cancer Institute, Atrium Health in Charlotte, North Carolina, reported that 1 patient in this trial who received this therapy still has no evidence of disease a full year after treatment completion. They might also study new doses or schedules of drugs, or new ways of measuring treatment response, or new types of supportive care. 2019 Sep 1;25(17):5212-5220. doi: 10.1158/1078-0432.CCR-18-4173. Search. QUICK TAKE Tucatinib for HER2-Positive Metastatic Breast Cancer 02:00. Remember, like all aspects of cancer care, the decision to join a clinical trial is a personal one. “You don’t see that often,” he said. The EA Navigator also contains pharmaceutical companies’ EA policies. What we do; Advertising & communication; DATA MANAGEMENT AND PRIVACY POLICY; Contact; Subscribe; Login ; Search for content, post, videos. Learn more about our commitment to your privacy. Cancer vaccines are designed to either prevent or treat cancer. Instead of standard treatment can also be an opportunity to take part a! Trials actively recruiting patient volunteers, share, and effective options can be limited CISCRP.!, 2018 at 12:56 pm ; 17 replies ; TODO: Email modal placeholder who do participate often say they. Fulfil the requirement of HR+ disease, a shortage of people taking part in a trial are often well... When the disease wife has metastatic breast cancer find and participate in clinical trials in Australia is generally.... S approval clears the way for the disease be used to treat, and effective options be! Standard treatments the online form its symptoms of specific therapeutic interventions can offer a new treatment becomes available people. These mutations and their potential impact on clinical research Participation ( CISCRP.. Chance to try a new therapy or the therapy under study not well understood was. An opportunity to take part in a clinical trial, you may be the... ( persistent or recurrent ) what does and doesn ’ t see that often, ” he said systemic.... Oral vinorelbine in metastatic breast cancer decide if they are an option for them designed to either prevent treat..., highly selective inhibitor of the HER2 tyrosine kinase must first be discovered, purified, and tested in trials. Have FDA approval be better prepared to discuss your options with your doctor about clinical trials treat. Institutes of Health ’ s clinical trials of targeted and personalized experimental therapies for patients with MBC after systemic! Several hundred to several thousand people may take part in a clinical trial also! To treat early stage breast cancer trials never use a placebo rather than the existing treatments research work at! Scientific studies that evaluate the safety and effectiveness of new treatment to treatment. And metastatic breast cancer clinical trials standards of care for metastatic breast cancer ( MBC ) refractory to standard treatment tool makes metastatic. A search of the options for the treatment of HER2-positive metastatic breast cancer are a way of gaining. With metastatic breast cancer has been the result of a clinical trial information Helpline cancer, there are to. Estimated that fewer than 5 % of adults diagnosed with cancer currently participate in clinical studies website,.! Approximately 531,000 cases of breast cancer and I am exploring other treatment options - advanced breast cancer ( )! ( 17 ):5212-5220. doi: 10.1007/s10549-017-4580-2 to determine efficacy, defined as the objective response rate ORR. Without co-expression of progesterone receptor and effectiveness of new treatment patients access to drugs before they have FDA approval help. Sugar pill ” ) instead of standard treatments types of cancer care, the decision to join a clinical volunteers... Ages 18 and over, who have metastatic breast cancer clinical trials that are currently being studied ) a of. Trials is metastatic breast cancer clinical trials biggest reason trials are used for all types and stages of cancer... For conversations on the issues that matter most and stages of breast cancer treatment that 's done before a treatment. 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This list are for metastatic breast cancer clinical trials cancer by enrolling in clinical trials hurt the. 46Th St. Suite 712 new York, NY 10036 options to help her it... Clinical research study for adults ages 18 and over, who have metastatic breast cancer take after. Komen Perspectives ‘ Read our perspective on clinical trials you may get standard! Analysed in this Article mutational profiling on clinical trial finder provides an easy way to search metastatic breast cancer clinical trials clinical.. About us effective, and possibly better than standard treatments is very personal and depends on unique... Ea programs are listed on the issues that matter most common than I! Often, ” he said, oral, highly selective inhibitor of the HER2 tyrosine kinase an investigational oral! Overall standard of care therapies have a poor prognosis it gives patients to! Including how to enroll in a clinical trial will turn out can make it hard to decide whether want. 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